Key result
Administering low molecular weight heparin 2 hours before versus 2 hours after hip replacement surgery resulted in similar rates of deep vein thrombosis (5.3% vs 4.8%).
Why the study?
Does administering the first dose of low molecular weight heparin 2 hours before versus 2 hours after surgery affect the incidence of deep vein thrombosis in patients undergoing hip replacement surgery?
Population
40 patients undergoing hip replacement surgery
Comparison
Low molecular weight heparin 15,000 aXaU single… vs Low molecular weight heparin 15,000 aXaU single…
Design
Cohort
Follow-up
7 days
Authors
Loading...
May not affect DVT prevention timing in hip replacement; hypothesis-generating and should not change practice without RCTs.
Does administering the first dose of low molecular weight heparin 2 hours before versus 2 hours after surgery affect the incidence of deep vein thrombosis in patients undergoing hip replacement surgery?
Absolute Event Rate: 5.3% vs 4.8%
The timing of the first dose of low molecular weight heparin (2 hours before vs 2 hours after surgery) does not significantly affect its efficacy in preventing deep vein thrombosis after hip replacement surgery.
Laguardia et al. (1992) studied Post-operative deep vein thrombosis in hip replacement surgery (n=40). Low molecular weight heparin ('Fluxum') 2 hours before surgery vs. Low molecular weight heparin ('Fluxum') 2 hours after surgery was evaluated on Incidence of deep vein thrombosis. Administering low molecular weight heparin 2 hours before versus 2 hours after hip replacement surgery resulted in similar rates of deep vein thrombosis (5.3% vs 4.8%).
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: