Key result
Low-dose heparin (5000 units every 8 hours) did not reduce the frequency of deep-vein thrombosis compared to placebo in patients with proximal femoral fractures.
Why the study?
Does low-dose heparin prevent deep-vein thrombosis in patients with proximal femoral fractures?
Population
130 patients with proximal femoral fractures
Comparison
Heparin 5000 units every 8 hours, administered… vs Placebo
Design
RCT, randomised, double blind
Follow-up
14 days
Authors
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Low-dose heparin does not prevent DVT in proximal femoral fractures; challenges prior efficacy assumptions and supports alternative prophylaxis trials.
RCT (n=130)
Double-blind
randomised
Does low-dose heparin prevent deep-vein thrombosis in patients with proximal femoral fractures?
Low-dose heparin administered every 8 hours for 14 days failed to prevent deep-vein thrombosis in patients with proximal femoral fractures.
Svend-Hansen et al. (1981) conducted an RCT in proximal femoral fractures (n=130). Heparin vs. Placebo was evaluated on deep venous thrombosis. Low-dose heparin (5000 units every 8 hours) did not reduce the frequency of deep-vein thrombosis compared to placebo in patients with proximal femoral fractures.
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