Key result
Ethacrynic acid administration in dogs caused a transient increase in heart rate and mean arterial pressure (P<0.005) and partially attenuated the vasodilatory response to nitroglycerin in vitro.
Why the study?
Does ethacrynic acid attenuate the response to nitroglycerin in dogs and isolated dog arteries?
Population
Dogs (in vivo groups including 6 dogs in group A; in vitro 75 rings of dorsal pedal artery from 14 dogs)
Comparison
Ethacrynic acid (0.75 mg/kg in vivo; 1.6 X 10 M… vs Before ethacrynic acid; saline; EA solvent
Design
Preclinical
Follow-up
60 min
Authors
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Ethacrynic acid should not alter nitroglycerin use in patients; leaves open translation of canine in vitro attenuation to human physiology.
Does ethacrynic acid attenuate the response to nitroglycerin in dogs and isolated dog arteries?
Absolute Event Rate: 9.4% vs 14.7%
Ethacrynic acid partially attenuates the vasodilatory response to nitroglycerin in vitro but does not significantly alter the systemic blood pressure response to nitroglycerin in vivo in dogs.
Moffat et al. (1985) studied this question. Ethacrynic acid vs. Baseline / Control was evaluated on Decline in systolic blood pressure in response to intravenous nitroglycerin. Ethacrynic acid administration in dogs caused a transient increase in heart rate and mean arterial pressure (P<0.005) and partially attenuated the vasodilatory response to nitroglycerin in vitro.
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