Heptakis[2,3‐di‐O‐methyl‐6‐O‐( L ‐valine‐tert‐butylamide‐Nα‐ylcarbonylmethyl)]‐β‐cyclodextrin: a New Multifunctional Cyclodextrin CSA for the NMR Enantiodiscrimination of Polar and Apolar Substrates

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Heptakis[2,3‐di‐O‐methyl‐6‐O‐(L‐valine‐tert‐butylamide‐Nα‐ylcarbonylmethyl)]‐β‐cyclodextrin with methyl groups on the secondary sites and a diamide chiral selector on the primary ones showed considerable utility as a CSA in the NMR enantiodiscrimination of a wide spectrum of amino acid derivatives, while also allowing trisubstituted allenes to be enantiodiscriminated. Enantiodiscrimination processes were investigated by Diffusion‐Ordered SpectroscopY (DOSY). (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)