Key result
The elimination half-life was 120 +/- 26 min for IGFBP-1 and 144 +/- 32 min for IGFBP-2 in anesthetized normal rats, suggesting equilibration with extravascular compartments.
Why the study?
What are the pharmacokinetic profiles of insulin-like growth factor binding proteins-1 and -2 in rats?
What are the pharmacokinetic profiles of insulin-like growth factor binding proteins-1 and -2 in rats?
IGFBP-1 and -2 have half-lives substantially greater than free IGF-I but less than the 150-kDa complex, suggesting they equilibrate with extravascular compartments and modulate transvascular transport.
No takes yet. Share an insight, caveat, or question.
Rat pharmacokinetic data are hypothesis-generating; human studies needed to clarify IGFBP-1/2 effects on IGF-I transport.
Young et al. (1992) studied Normal rats. 125I-IGFBP-1 and 2 was evaluated on Pharmacokinetic profiles (mean residence time, volume of distribution, elimination half-life). The elimination half-life was 120 +/- 26 min for IGFBP-1 and 144 +/- 32 min for IGFBP-2 in anesthetized normal rats, suggesting equilibration with extravascular compartments.
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