Key result
Neurological symptoms occurring after carotid cross-clamping during carotid endarterectomy significantly correlated with an increase in serum S100B levels (median increase 36.2% vs -2.7% in asymptomatic patients).
Why the study?
To investigate whether elevated serum S100B levels or decreased rSO2 after carotid revascularization with CEA could detect neurological instability.
Does monitoring of serum S100B and rSO2 predict neurological instability in patients undergoing carotid endarterectomy under local anesthesia?
Observational (n=60)
No
Does monitoring of serum S100B and rSO2 predict neurological instability in patients undergoing carotid endarterectomy under local anesthesia?
Answers are grounded in this paper and cite their sources.
While an increase in serum S100B during carotid endarterectomy correlates with neurological symptoms, its long assessment time limits its practical utility for real-time perioperative neuromonitoring.
The aim of this pilot investigation was to see if a raised serum S100B level or a decrease in rSO 2 following carotid revascularization with CEA might be used to detect neurological instability in CEA patients. Increased serum S100B levels during CEA, we hypothesized, would be linked to neurological symptoms after surgery. Patients and methods: A total of 64 consecutive CEAs in 60 patients operated under LA (local anesthesia) during an 18-month period were prospectively evaluated. The cerebral oximeter was used to measure cerebral oxygen saturation (rSO2) before and after cross-clamping along with serum. concentration of S100B protein. Selective shunting was performed when neurological changes occurred, regardless of NIRS.
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Matej Makovec (2022) conducted an observational in Severe carotid artery stenosis (n=60). Elevated serum S100B levels vs. Non-elevated serum S100B levels was evaluated on Neurological symptoms during carotid cross-clamping (p=0.040). Neurological symptoms occurring after carotid cross-clamping during carotid endarterectomy significantly correlated with an increase in serum S100B levels (median increase 36.2% vs -2.7% in asymptomatic patients).
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