Key result
Carotid shunting during CEA is linked to a ~60% increase in serum neuron-specific enolase.
Why the study?
The diagnostic value and specificity of nerve tissue protein S-100 and neurone-specific enolase in serum and cerebrospinal fluid during carotid endarterectomy for detecting cerebral damage were uncertain.
Do nerve tissue protein S-100 and neurone-specific enolase concentrations in cerebrospinal fluid and blood indicate cerebral damage during elective carotid endarterectomy?
Population
10 patients undergoing elective carotid endarterectomy under general anaesthesia with Javid Shunt
Comparison
Serum and cerebrospinal fluid levels of nerve tissue protein S-100 and neurone-specific enolase before, during, and after surgery
Design
Observational study
Follow-up
2 days postoperatively for biomarkers, 6 months for neurological deficits
Authors
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Serum NSE and S-100 lack reliability for minor cerebral damage during CEA; leaves open CSF S-100 as a potential biomarker pending validation.
Observational (n=10)
Do nerve tissue protein S-100 and neurone-specific enolase concentrations in cerebrospinal fluid and blood indicate cerebral damage during elective carotid endarterectomy?
Cerebrospinal fluid nerve tissue protein S-100 may be a sensitive marker for minor cerebral damage during carotid endarterectomy, whereas serum S-100 and neurone-specific enolase appear less reliable.
Gao et al. (2000) conducted an observational in Elective carotid endarterectomy (n=10). Carotid endarterectomy vs. Baseline (before surgery) was evaluated on Nerve tissue protein S-100 and neurone-specific enolase levels in serum and cerebrospinal fluid. During carotid endarterectomy, serum neurone-specific enolase increased from 5.8 to 9.3 microg/L during shunting, while serum S-100 remained normal in uncomplicated cases.
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