Key result
Protein-bound leptin concentrations, but not free leptin levels, were significantly correlated with basal muscle sympathetic nerve activity in normotensive, nonobese men (r2 = 0.35; P < 0.01).
Population
25 normotensive, nonobese men, 8 patients with central autonomic failure, and 4 patients with peripheral…
Design
Cross-sectional
Authors
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Does not support clinical use of leptin fractions for sympathetic assessment; hypothesis-generating for autonomic regulation in lean normotensives.
Cross-Sectional (n=37)
Effect estimate: r2 = 0.35
p-value: p=<0.01
Protein-bound leptin, rather than free leptin, is correlated with basal sympathetic outflow in normotensive, nonobese men, potentially via a baroreflex mechanism.
Tank et al. (2003) conducted a cross-sectional in Normotensive, nonobese men and autonomic failure (n=37). Protein-bound leptin vs. Free leptin was evaluated on Correlation between muscle sympathetic nerve activity (MSNA) and protein-bound leptin concentrations (r2 = 0.35, p=<0.01). Protein-bound leptin concentrations, but not free leptin levels, were significantly correlated with basal muscle sympathetic nerve activity in normotensive, nonobese men (r2 = 0.35; P < 0.01).
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