Why the study?
Does autonomic blockade affect the development or maintenance of ACTH-induced hypertension in conscious sheep?
Does autonomic blockade affect the development or maintenance of ACTH-induced hypertension in conscious sheep?
In a sheep model, the sympathetic nervous system is not essential for ACTH-induced hypertension, though baroreceptor reflexes normally suppress the pressor response.
Autonomic integrity not required for ACTH hypertension in sheep; hypothesis-generating for non-autonomic mechanisms in clinical steroid-induced hypertension.
The roles of the autonomic nervous system, renin-angiotensin system, and arginine vasopressin (AVP) during the onset of ACTH-induced hypertension were investigated in conscious sheep. Autonomic ganglion blockade or combined adrenergic and cholinergic receptor blockade demonstrated that an intact sympathetic nervous system was not essential for the development or maintenance of the hypertension. Autonomic blockade augmented the pressor response to ACTH, indicating that baroreceptor-mediated reflexes normally operate to suppress the degree of hypertension produced by ACTH. Evidence was obtained suggesting that the renin-angiotensin system and AVP may partially contribute to the maintenance of ACTH hypertension in the presence of autonomic blockade. However, the precise mechanism by which ACTH raises arterial pressure remains to be elucidated.
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Spence et al. (1987) studied this question.
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