Key result
The ACE II genotype was associated with a decreased risk of diabetic nephropathy in NIDDM patients, being less frequent compared to patients without nephropathy (p<0.01).
Why the study?
Is the angiotensin-converting enzyme insertion/deletion (I/D) polymorphism associated with the development of diabetic nephropathy in Japanese patients with NIDDM?
Population
111 Japanese patients with non-insulin-dependent diabetes mellitus of at least 10 years duration and 76…
Comparison
Angiotensin-converting enzyme insertion/deletion… vs Patients without nephropathy and healthy controls
Design
Case-control
Authors
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ACE II genotype may influence diabetic nephropathy risk in NIDDM; hypothesis-generating and should not yet change practice.
Case-Control (n=187)
Is the angiotensin-converting enzyme insertion/deletion (I/D) polymorphism associated with the development of diabetic nephropathy in Japanese patients with NIDDM?
p-value: p=<0.01
The II genotype of the angiotensin-converting enzyme insertion/deletion polymorphism is associated with a decreased risk for the development of diabetic nephropathy in Japanese patients with NIDDM.
Mizuiri et al. (2008) conducted a case-control in Non-insulin-dependent diabetes mellitus (NIDDM) and diabetic nephropathy (n=187). Angiotensin-converting enzyme insertion/deletion (I/D) polymorphism vs. Patients without nephropathy and healthy controls was evaluated on Distribution frequency of ACE I/D polymorphism (p=<0.01). The ACE II genotype was associated with a decreased risk of diabetic nephropathy in NIDDM patients, being less frequent compared to patients without nephropathy (p<0.01).
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