Key result
Maitotoxin (500 pM) activated a cationic current in human skin fibroblasts carried by Na+, K+, and Ca2+, which required both extracellular and intracellular Ca2+ for activation.
Maitotoxin activates a non-selective cationic current in human skin fibroblasts that is dependent on both intra- and extracellular calcium.
No takes yet. Share an insight, caveat, or question.
No immediate clinical implications for cardiovascular care; hypothesis-generating for maitotoxin effects on human cells and warrants cardiac-specific investigation.
Martínez‐François et al. (2002) studied this question. Maitotoxin (MTX) vs. Resting conditions (absence of MTX) was evaluated on Cationic current characteristics (I(mtx)). Maitotoxin (500 pM) activated a cationic current in human skin fibroblasts carried by Na+, K+, and Ca2+, which required both extracellular and intracellular Ca2+ for activation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: