Key result
Initiation of Sendai virus Y1 and Y2 proteins occurs via a ribosomal shunt or discontinuous scanning, delivering the scanning complex directly to the Y start codons.
Population
Sendai virus P/C mRNA translation model
Comparison
Mutational analysis of initiation codons vs Wild-type or other mutant constructs
Design
Preclinical
Authors
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No immediate clinical implications; leaves open ribosomal shunting as antiviral target in related viruses.
Sendai virus Y proteins are initiated via a ribosomal shunt mechanism that delivers the scanning complex directly to the Y start codons.
Latorre et al. (1998) studied Sendai virus infection. Ribosomal shunt was evaluated. Initiation of Sendai virus Y1 and Y2 proteins occurs via a ribosomal shunt or discontinuous scanning, delivering the scanning complex directly to the Y start codons.
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