Key result
Sequence analysis of the rotavirus NS35 gene revealed high conservation among mammalian strains (≥83%) and identified a conserved basic domain that may serve as the RNA-binding domain.
Population
Mammalian and avian rotaviruses (Wa, DS1, SA11 [Patton and Ramig strains], NCDV, Ty-1, OSU, and UK)
Design
Preclinical
Authors
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Conserved NS35 basic domain in mammalian rotaviruses may guide antiviral targeting; leaves open functional validation and avian divergence.
The NS35 protein of rotaviruses contains a highly conserved basic domain that may serve as an RNA-binding domain, with significant divergence between mammalian and avian strains.
Patton et al. (1993) studied Rotavirus. Sequence analysis of NS35 gene was evaluated on Nucleotide and amino acid sequence conservation. Sequence analysis of the rotavirus NS35 gene revealed high conservation among mammalian strains (≥83%) and identified a conserved basic domain that may serve as the RNA-binding domain.
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