Key result
Cardiac sequelae at the initial episode of Kawasaki disease was associated with a 47% rate of sequelae after recurrence, compared to 16% in patients without initial sequelae.
Why the study?
What is the risk of developing cardiac sequelae after a recurrence of Kawasaki disease compared to the initial episode?
Population
559 patients with recurrent Kawasaki disease recorded between 1989 and 1994 from the Japanese Kawasaki…
Design
Cohort
Authors
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May warrant closer surveillance upon recurrence in those with initial sequelae; leaves open optimal risk-stratification strategies pending prospective validation.
Cohort (n=559)
Yes
What is the risk of developing cardiac sequelae after a recurrence of Kawasaki disease compared to the initial episode?
Absolute Event Rate: 47% vs 16%
The risk of developing cardiac sequelae after recurrent Kawasaki disease is high, regardless of whether sequelae were present during the initial episode, with older age at recurrence and longer interval between episodes as suspected risk factors.
Nakamura et al. (1998) conducted a cohort in Kawasaki disease (n=559). Cardiac sequelae at initial episode vs. No cardiac sequelae at initial episode was evaluated on Cardiac sequelae after the second onset (recurrence). Cardiac sequelae at the initial episode of Kawasaki disease was associated with a 47% rate of sequelae after recurrence, compared to 16% in patients without initial sequelae.
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