Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 1, 1997Arteriosclerosis Thrombosis and Vascular BiologyOpen Access

The Angiotensin-Converting Enzyme Gene and the Angiotensin II Type I Receptor Gene as Candidate Genes for Microalbuminuria

View Full Paper
Ask AI
Bookmark
Share

Key result

Polymorphisms of the ACE and AT1R genes were not significantly associated with differences in albumin excretion rate in nondiabetic or non-insulin-dependent diabetic subjects.

Why the study?

Do polymorphisms in the ACE and AT1R genes associate with microalbuminuria in nondiabetic and non-insulin-dependent diabetic subjects?

Population

595 white subjects, comprising 509 nondiabetic subjects and 86 non-insulin-dependent diabetic patients.

Comparison

Angiotensin-converting enzyme DD genotype and… vs Other genotypes of the ACE and AT1R genes

Design

Cross-sectional

Authors

JYJohn YudkinGeneral / Preventive / LipidsCAChristine AndrèsUniversity of StuttgartVMVidya Mohamed‐AliCentre for Inflammation Research

Discussion

Loading...

Member takes

Implication

No association with ACE/AT1R polymorphisms and albumin excretion; leaves open other genetic factors in microalbuminuria among nondiabetic and NIDDM subjects.

Study Design

Type

Cross-Sectional (n=595)

Structured PICO

Do polymorphisms in the ACE and AT1R genes associate with microalbuminuria in nondiabetic and non-insulin-dependent diabetic subjects?

P
Population
595 white subjects (509 nondiabetic and 86 with non-insulin-dependent diabetes) evaluated for the association between ACE/AT1R gene polymorphisms and microalbuminuria.
E
Exposure
Angiotensin-converting enzyme (ACE) DD genotype and angiotensin II type I receptor (AT1R) gene C allele
C
Comparator
Other genotypes of the ACE and AT1R genes
O
Outcome
Albumin excretion rate (microalbuminuria)surrogate

Polymorphisms in the ACE and AT1R genes are not associated with microalbuminuria in nondiabetic or non-insulin-dependent diabetic white subjects.

Cite This Study

Yudkin et al. (1997) conducted a cross-sectional in Microalbuminuria (n=595). ACE DD genotype and AT1R gene C allele vs. Other genotypes was evaluated on Albumin excretion rate. Polymorphisms of the ACE and AT1R genes were not significantly associated with differences in albumin excretion rate in nondiabetic or non-insulin-dependent diabetic subjects.

synapsesocial.com/papers/6a9455565cc4cfd2f72dd278https://doi.org/10.1161/01.atv.17.10.2188
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Genetic Predisposition to Diabetic Nephropathy: Evidence for a Role of the Angiotensin I–Converting Enzyme Gene1994 · 186 citations
  2. 2Relationships Between Angiotensin I Converting Enzyme Gene Polymorphism, Plasma Levels, and Diabetic Retinal and Renal Complications1994 · 366 citations
  3. 3Polymorphisms of the angiotensin-converting-enzyme gene in subjects who die from coronary heart disease1994 · 216 citations
  4. 4Angiotensin I-Converting Enzyme Gene Polymorphism Is Associated With Myocardial Infarction, but Not With Retinopathy or Nephropathy, in NIDDM1995 · 99 citations
  5. 5Effect of deletion polymorphism of angiotensin converting enzyme gene on progression of diabetic nephropathy during inhibition of angiotensin converting enzyme: observational follow up study1996 · 186 citations