Key result
The D allele of the ACE gene was associated with the risk of chronic kidney disease among hypertensive patients (OR 1.25; 95% CI 0.86-1.79).
Why the study?
Does ACE-1 gene polymorphism increase the risk of chronic kidney disease in hypertensive patients?
Case-Control (n=300)
Does ACE-1 gene polymorphism increase the risk of chronic kidney disease in hypertensive patients?
Odds Ratio: 1.25 (95% CI 0.86–1.79)
The ACE-DD genotype and D allele may be associated with an increased risk of developing chronic kidney disease among hypertensive patients.
ACE genotyping should not guide CKD prevention in hypertension yet; leaves open a modest D-allele association requiring confirmation.
BACKGROUND: Hypertension is one of the important contributing factors linked with both causation and development of kidney disease. It is a multifactorial, polygenic, and complex disorder due to interaction of several risk genes with environmental factors. The present study was aimed to explore genetic polymorphism in ACE-1 gene as a risk factor for CKD among hypertensive patients. METHODS: Three hundred patients were enrolled in the study. Ninety were hypertensive patients with CKD taken as cases, whereas 210 hypertensive patients without CKD were taken as controls. Demographic data including age, sex, Body mass index (BMI), and other risk factors were also recorded. DNA was extracted from blood by salting out method. Genotyping of ACE gene was done by PCR technique. All the statistical analysis was done by using Epi Info and SPSS version 16 software (SPSS Inc., Chicago, IL). RESULTS: Mean age was higher in the control group (p < 0.05). Variables among two groups were compared out of which age, BMI, hemoglobin (Hb) was found to be statistically significant whereas other variables like systolic blood pressure, triglyceride and low-density lipoprotein were not. Blood urea and serum creatinine levels were statistically significant in the two genotypes (p < 0.05). Total and HDL cholesterol were statistically significant for DD genotype of ACE gene (OR = 1.42, 95% CI = 0.72-2.81). Similarly, the risk for CKD among hypertensive patients was also associated with D allele of ACE gene (OR = 1.25, 95% CI = 0.86-1.79). CONCLUSION: It is concluded that ACE-DD genotype may be a risk factor for the causation and development of chronic kidney failure among hypertensive patients.
No takes yet. Share an insight, caveat, or question.
Sarkar et al. (2016) conducted a case-control in Hypertension and chronic kidney disease (n=300). ACE-1 gene D allele vs. Non-D allele was evaluated on Chronic kidney disease (OR 1.25, 95% CI 0.86-1.79). The D allele of the ACE gene was associated with the risk of chronic kidney disease among hypertensive patients (OR 1.25; 95% CI 0.86-1.79).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: