Dextran Sulfate Plaque Variants of Attenuated Type 1 Poliovirus

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Population

NIH reference attenuated, type 1 poliovirus, NA-2 and monkeys used for intrathalamic inoculation

Design

Preclinical

Authors

Discussion

Distinguishes poliovirus variants by neurovirulence in monkeys; leaves open translation to human vaccine testing.

Population

NIH reference attenuated, type 1 poliovirus, NA-2 (Sabin strain) and monkeys used for intrathalamic inoculation

Intervention

Dextran sulfate (dex-s) in the overlay medium to isolate plaque variants (ds+ and ds-)

Outcome

Plaque types, d and rct/40 markers, histologic lesions of poliomyelitis, and paralysissurrogate

Dextran sulfate overlay identifies plaque variants of attenuated type 1 poliovirus with differing marker profiles and neurovirulence in monkeys.

Takemoto et al. (1964) studied this question.

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