Key result
The degree of histoincompatibility and anti-HLA antibody status did not significantly impact homograft valve function at a mean follow-up of 15 months after the Ross procedure.
Why the study?
Does histocompatibility affect homograft valve function after the Ross procedure?
Population
26 patients undergoing the Ross procedure with cryopreserved pulmonary homograft valves.
Design
Cohort
Follow-up
mean 15±6 months
Authors
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Histoincompatibility does not appear to affect short-term homograft function after Ross; leaves open whether HLA matching influences longer-term durability.
Cohort (n=26)
Does histocompatibility affect homograft valve function after the Ross procedure?
Histoincompatibility does not appear to significantly impact homograft valve function within the first 15 months after a Ross procedure, whereas smaller homograft size and younger recipient age are associated with increased pressure gradients.
Bechtel et al. (2001) conducted a cohort in Patients undergoing the Ross procedure (n=26). Histoincompatibility (HLA mismatches) vs. Histocompatibility (fewer or no HLA mismatches) was evaluated on Echocardiographic parameters of homograft valve function (transhomograft pressure gradients and regurgitation). The degree of histoincompatibility and anti-HLA antibody status did not significantly impact homograft valve function at a mean follow-up of 15 months after the Ross procedure.
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