Key result
The degree of histoincompatibility had no significant impact on homograft valve function at 15 months, whereas smaller homograft size (P=0.001) and younger age (P=0.044) increased pressure gradients.
Why the study?
Does histocompatibility affect homograft valve function after the Ross procedure?
Population
26 patients who underwent a Ross procedure with cryopreserved pulmonary homograft valves
Design
Cohort
Follow-up
mean 15+/-6 months
Authors
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Findings do not support histocompatibility matching for early homograft function after Ross; leaves open whether size and age warrant refined selection.
Cohort (n=26)
Does histocompatibility affect homograft valve function after the Ross procedure?
Histoincompatibility and the resulting humoral response do not appear to significantly affect homograft valve function within the first 15 months after the Ross procedure.
Bechtel et al. (2001) conducted a cohort in Ross procedure (n=26). Histoincompatibility (HLA mismatches) was evaluated on Homograft valve function (transhomograft pressure gradients and regurgitation). The degree of histoincompatibility had no significant impact on homograft valve function at 15 months, whereas smaller homograft size (P=0.001) and younger age (P=0.044) increased pressure gradients.
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