Key result
Overexpression of Ang-2 significantly inhibited nasopharyngeal carcinoma tumor growth and reduced microvessel density (9.48 vs 22.89) when endogenous VEGF expression was silenced.
Absolute Event Rate: 9.48% vs 22.89%
p-value: p=<0.01
Ang-2 overexpression suppresses nasopharyngeal carcinoma tumor growth and angiogenesis only when VEGF levels are low, suggesting the Ang-2/VEGF ratio is a critical determinant of tumor progression.
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Ang-2 modulation may influence tumor angiogenesis depending on VEGF status; hypothesis-generating in animal models and leaves open human relevance.
Chen et al. (2014) studied Nasopharyngeal carcinoma (n=54). Ang-2 overexpression and VEGF silencing vs. Mock, control plasmid, Ang-2 plasmid, Ang-2 + scrambled miRNA, VEGF miRNA was evaluated on Microvessel density (MVD) (p=<0.01). Overexpression of Ang-2 significantly inhibited nasopharyngeal carcinoma tumor growth and reduced microvessel density (9.48 vs 22.89) when endogenous VEGF expression was silenced.