Key result
Enterovirus D68 infection was detected in 10 of 3,071 (0.33%) children hospitalized with acute lower respiratory tract infection, with all cases presenting as mild disease without neurological symptoms.
Why the study?
EV-D68 infection related acute flaccid paralysis has attracted attention since a 2014 outbreak in the USA, and EV-D68 was detected in a child with acute flaccid paralysis for the first time in China in 2018.
Observational (n=3,071)
Yes
EV-D68 subclade B3 is present in a small proportion of pediatric ALRTI cases in China and exhibits potential neuropathic capacity in vitro.
Background EV-D68 infection related acute flaccid paralysis (AFP) attracts much attention since the outbreak in the USA in 2014. Notably, EV-D68 was detected from a child with acute flaccid paralysis for the first time in China in 2018. Methods Based on a multicentre study monitoring viral pathogens of acute lower respiratory tract infection in children in China from May 2017 to December 2019, 10 EV-D68 positive specimens were detected from 3071 samples. Results These 10 patients presented with mild diseases and no neurological symptoms and signs. The phylogenetic analysis shows that all 10 obtained sequences belong to subclade B3 which circulates dominantly at present all over the world and shares high identity with strains related to AFP in the USA. Moreover, four EV-D68 strains are successfully isolated and it is worth noting that the isolate in this study is able to infect “neuronal-like” cell line SH-SY5Y which was used to identify the neurotropism of enteroviruses. Further, amino acid and nucleotide sites related to neurovirulence were analyzed, but these analysis results are not enough to explain the ability of our strains to infect SH-SY5Y cells. This suggests that the EV-D68 isolate in China has potential neuropathic capacity. Conclusions In conclusion, EV-D68 infection was detected in a small number of children with acute lower respiratory tract infections in China from 2017 to 2019. The genotype of EV-D68 in this study is B3, which has the ability to infect “neuronal-like” cell line SH-SY5Y.
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Li et al. (2022) conducted an observational in Acute lower respiratory tract infection (n=3,071). Enterovirus D68 infection was evaluated on Detection of EV-D68 infection. Enterovirus D68 infection was detected in 10 of 3,071 (0.33%) children hospitalized with acute lower respiratory tract infection, with all cases presenting as mild disease without neurological symptoms.
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