June 1, 2001PEDIATRICS
Prothrombotic Disorders and Abnormal Neurodevelopmental Outcome in Infants With Neonatal Cerebral Infarction
Key result
The factor V Leiden mutation was significantly associated with poor neurologic outcome, with hemiplegia occurring in 100% of infants with the mutation compared to 21% of those without.
Why the study?
Do prothrombotic disorders increase the risk of poor neurologic outcome in infants with neonatal cerebral infarction?
Population
24 infants with perinatal cerebral infarction confirmed by neonatal MRI
Comparison
Presence of inherited and acquired prothrombotic… vs Absence of prothrombotic disorders
Design
Cohort
Authors
Discussion
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Implication
Factor V Leiden association with hemiplegia should not yet change practice; leaves open whether screening improves outcomes in neonatal stroke.
Study Design
Type
Cohort (n=24)
Structured PICO
Do prothrombotic disorders increase the risk of poor neurologic outcome in infants with neonatal cerebral infarction?
P
Population
24 infants with perinatal cerebral infarction confirmed by neonatal MRI evaluated for inherited and acquired prothrombotic disorders.
E
Exposure
Presence of inherited and acquired prothrombotic disorders (e.g., factor V Leiden, high factor VIIIc)
C
Comparator
Absence of prothrombotic disorders
O
Outcome
Type of infarct on MRI (presence of cerebral hemorrhage) and clinical/neurologic outcome (hemiplegia or global developmental delay)hard clinical
Main Result
Absolute Event Rate: 100% vs 21%
The presence of prothrombotic risk factors, particularly factor V Leiden, is significantly associated with poor neurologic outcomes after perinatal cerebral infarction.
Cite This Study
Mercuri et al. (2001) conducted a cohort in Neonatal cerebral infarction (n=24). Factor V Leiden mutation vs. Absence of Factor V Leiden mutation was evaluated on Hemiplegia. The factor V Leiden mutation was significantly associated with poor neurologic outcome, with hemiplegia occurring in 100% of infants with the mutation compared to 21% of those without.