Key result
Visit-to-visit variability of blood pressure was not significantly associated with the rate of renal function decline in patients with diabetic chronic kidney disease.
Why the study?
Does visit-to-visit variability of blood pressure correlate with renal function decline in patients with diabetic chronic kidney disease?
Observational (n=69)
No
Does visit-to-visit variability of blood pressure correlate with renal function decline in patients with diabetic chronic kidney disease?
Unlike in nondiabetic chronic kidney disease, visit-to-visit blood pressure variability does not appear to be significantly associated with renal function decline in patients with diabetic chronic kidney disease.
Answers are grounded in this paper and cite their sources.
Null finding cautions against generalizing BP variability as renal risk factor in diabetic CKD; leaves open etiology-specific effects and prospective validation.
The authors previously reported that the visit-to-visit variability of blood pressure is correlated with renal function decline in nondiabetic chronic kidney disease. Little is known about the association between visit-to-visit variability and renal function decline in patients with diabetic chronic kidney disease. The authors retrospectively studied 69 patients with diabetic chronic kidney disease stage 3a, 3b, or 4. The standard deviation and coefficient of variation of blood pressure in 12 consecutive visits were defined as visit-to-visit variability of blood pressure. The median observation period was 32 months. In univariate correlation, the standard deviation and coefficient of variation of blood pressure were not significantly associated with the slope of estimated glomerular filtration rate. There was no significant association between the visit-to-visit variability of blood pressure and renal function decline in patients with diabetic chronic kidney disease, in contrast with our previous study of nondiabetic patients with chronic kidney disease.
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Yokota et al. (2014) conducted an observational in Diabetic chronic kidney disease (n=69). Visit-to-visit variability of blood pressure was evaluated on Rate of decline in renal function (yearly decrease in eGFR) (ρ=-0.04, p=0.74). Visit-to-visit variability of blood pressure was not significantly associated with the rate of renal function decline in patients with diabetic chronic kidney disease.
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