Key result
UDP (0.01 to 3 mmol/L) induced increases in tension and inward current oscillations in rat pulmonary arteries that were insensitive to suramin, suggesting a novel UDP receptor.
The study provides functional and molecular evidence for a novel suramin-insensitive UDP receptor (likely P2Y6) in rat pulmonary arterial smooth muscle cells that contributes to pyrimidine-evoked vasoconstriction.
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May identify a novel UDP receptor in pulmonary arteries; leaves open its role in human vascular disease.
Hartley et al. (1998) studied this question. UTP and UDP was evaluated on increase in tension and oscillations of inward current. UDP (0.01 to 3 mmol/L) induced increases in tension and inward current oscillations in rat pulmonary arteries that were insensitive to suramin, suggesting a novel UDP receptor.
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