Key result
UTP appears to drive porcine coronary artery contraction predominantly via P2Y2 receptors.
Why the study?
The specific P2Y receptor subtypes mediating uracil nucleotide-induced vasoconstriction in porcine coronary and ear artery smooth muscle were not clearly defined.
UTP-evoked contraction of porcine coronary artery smooth muscle is predominantly P2Y2-mediated, whereas the ear artery expresses an unclassified uracil nucleotide-sensitive P2 receptor.
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In vitro P2Y mapping in porcine arteries warrants caution in extrapolation; leaves open subtype roles in human coronary tone.
Rayment et al. (2007) studied this question. UTP and UDP vs. Absence and presence of PPADS or suramin was evaluated on Contractile responses and receptor expression. UTP-evoked contraction of porcine coronary artery smooth muscle appears to be predominantly P2Y2-mediated, while the ear artery expresses an unclassified uracil nucleotide-sensitive P2 receptor.
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