Key result
Low dose diamorphine administered immediately before exercise testing significantly reduced the ventilatory response to exercise (VE-VCO2 slope 31.19 vs 32.75, p=0.048) in patients with chronic heart failure.
Why the study?
Does low dose diamorphine improve ventilatory responses and aerobic exercise capacity in patients with stable chronic heart failure?
RCT (n=16)
Double-blind
Randomized
No
Does low dose diamorphine improve ventilatory responses and aerobic exercise capacity in patients with stable chronic heart failure?
Absolute Event Rate: 31.19% vs 32.75%
p-value: p=0.048
Low dose intravenous diamorphine acutely improves aerobic exercise capacity and reduces the exaggerated ventilatory response to exercise in patients with stable chronic heart failure.
No takes yet. Share an insight, caveat, or question.
May improve exertional tolerance in stable HF; extends opioid modulation of ventilatory control to randomized data.
Simon G. Williams (2003) conducted an RCT in Chronic heart failure (n=16). Diamorphine vs. Placebo was evaluated on Ventilatory response to exercise (VE-VCO2 slope) (p=0.048). Low dose diamorphine administered immediately before exercise testing significantly reduced the ventilatory response to exercise (VE-VCO2 slope 31.19 vs 32.75, p=0.048) in patients with chronic heart failure.
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