Why the study?
Does infectious bursal disease virus infection suppress the antiviral immune response to turkey herpesvirus vaccination in chickens?
Does infectious bursal disease virus infection suppress the antiviral immune response to turkey herpesvirus vaccination in chickens?
IBDV infection significantly suppresses the virus-neutralizing antibody response to HVT vaccination in chickens, potentially reducing antiviral immunity against Marek's disease.
IBDV may impair HVT vaccine responses in chickens; leaves open whether interference affects field efficacy or other poultry vaccines.
Studies were made to determine whether infectious bursal disease virus (IBDV) infection would affect the response of chickens to turkey herpesvirus (HVT) vaccination in the development and level of HVT viremia and virus-neutralizing (VN) antibodies to HVT. The HVT viremia in the vaccinated chickens was not affected by IBDV, whether IBDV was inoculated simultaneously with HVT vaccination at one day of age or whether it was inoculated 3 weeks postvaccination with HVT. However, VN antibody response to HVT was significantly suppressed (P less than 0.001) when vaccinated chickens were exposed to IBDV either at the time of vaccination or at 3 weeks postvaccination. Such immunosuppression by IBDV of VN antibody response to HVT vaccination may result in a reduced antiviral immunity against Marek's disease virus.
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Jen et al. (1980) studied this question.
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