Key result
An ~9% decline in [ATP] during submaximal muscular contractions led to the formation of inosine monophosphate, preserving a favorable energy state by minimizing large increases in [ADP].
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IMP formation during submaximal contractions preserves the cellular energy state by minimizing ADP increases, providing a mechanistic link between ATP loss and impaired energetic capacity in vivo.
An ∼9% decline in [ATP] led to the formation of inosine monophosphate (IMP) during submaximal muscular contractions. Modeling revealed IMP formed to preserve a favorable energy state (ΔG ATP ) by minimizing large increases in [ADP], whereas the loss of [ATP] did not alter ΔG ATP . [ATP] did not recover by 10 min, and the loss of [ATP] was associated with a reduced oxidative capacity, providing a new link between [ATP] loss and an impaired energetic capacity in vivo.
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Smith et al. (2024) studied this question. Submaximal muscular contractions was evaluated on Inosine monophosphate (IMP) formation and energy state (ΔG ATP). An ~9% decline in [ATP] during submaximal muscular contractions led to the formation of inosine monophosphate, preserving a favorable energy state by minimizing large increases in [ADP].
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