Switching Back to Normal Diet Following High-Fat Diet Feeding Reduces Cardiac Vulnerability to Ischaemia and Reperfusion Injury
Key result
Switching from a high-fat diet back to a normal diet reduced cardiac vulnerability to ischaemia and reperfusion injury in mice.
Why the study?
Does switching from a high-fat diet back to a normal diet reduce cardiac vulnerability to ischaemia and reperfusion injury in mice?
Population
Male C57BL/6J mice fed a high-fat diet for 19-22 weeks
Comparison
Switched back to normal diet for 4-6 weeks vs Mice fed only high-fat diet
Design
Preclinical
Follow-up
4-6 weeks
Authors
Discussion
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Member takes
Implication
No immediate clinical dietary changes indicated; leaves open translation of reversible cardioprotection from mouse models to humans.
Structured PICO
Does switching from a high-fat diet back to a normal diet reduce cardiac vulnerability to ischaemia and reperfusion injury in mice?
P
Population
Male C57BL/6J mice fed a high-fat diet for 19-22 weeks, with a subset switched back to normal diet for 4-6 weeks to assess cardiac vulnerability to ischaemia and reperfusion injury.
I
Intervention
Switched back to normal diet for 4-6 weeks
C
Comparator
Mice fed only high-fat diet
O
Outcome
Vulnerability to ischaemia and reperfusion (I/R) injurysurrogate
Switching from a high-fat diet back to a normal diet reduces cardiac vulnerability to ischaemia and reperfusion injury in a mouse model.
Cite This Study
Littlejohns et al. (2014) studied Ischaemia and reperfusion injury. Switching back to normal diet vs. High-fat diet only was evaluated on Resistance to reperfusion injury. Switching from a high-fat diet back to a normal diet reduced cardiac vulnerability to ischaemia and reperfusion injury in mice.