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January 1, 1987Clinical Science

Plasma atrial natriuretic peptide: Its relationship to changes in sodium intake, plasma renin activity and aldosterone in man

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Why the study?

Does dietary sodium intake affect plasma levels of atrial natriuretic peptide, renin activity, aldosterone, and vasopressin in normotensive subjects?

Population

11 normotensive subjects

Comparison

Varying dietary sodium intake vs Within-subject comparison across different…

Design

Other

Follow-up

5 days per diet phase

Authors

GSGiuseppe A. SagnellaUniversity of LondonNMNirmala D. MarkanduGeneral / Preventive / LipidsASAngela C. ShoreVascular Medicine

Discussion

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Implication

IrANP rises with sodium intake in normotensives; confirms physiologic role in sodium balance but leaves open clinical relevance.

Structured PICO

Does dietary sodium intake affect plasma levels of atrial natriuretic peptide, renin activity, aldosterone, and vasopressin in normotensive subjects?

P
Population
11 normotensive subjects
I
Intervention
Varying dietary sodium intake (low: 10 mmol/day, normal: 150 mmol/day, and high: 350 mmol/day)
C
Comparator
Within-subject comparison across different sodium intake levels
O
Outcome
Plasma levels of immunoreactive atrial natriuretic peptide (IrANP), plasma renin activity, aldosterone and vasopressinsurrogate

Dietary sodium intake directly correlates with plasma atrial natriuretic peptide levels, suggesting its role in physiological sodium and water balance.

Cite This Study

Sagnella et al. (1987) studied this question.

synapsesocial.com/papers/6a953c1e6a42edee3f2ca27fhttps://doi.org/10.1042/cs0720025
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Change in plasma immunoreactive atrial natriuretic peptide during sequential ultrafiltration and haemodialysis1986 · 80 citations
  2. 2The plasma release of atrial natriuretic peptide in man1986 · 132 citations
  3. 3Atrial natriuretic peptide: an endogenous factor enhancing sodium excretion in man1986 · 71 citations
  4. 4Atrial natriuretic factor in human blood.1985 · 247 citations
  5. 5Physiologic regulation of atrial natriuretic peptide receptors in rat renal glomeruli.1985 · 229 citations