November 1, 1987Clinical Science
Diurnal change in plasma atrial natriuretic peptide concentrations
Population
7 normal volunteers
Follow-up
24 hours diurnal study plus 2 days of sodium depletion
Authors
Discussion
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Member takes
Implication
May warrant time-of-day adjustment in ANP assessment; leaves open effects on outcomes or therapy timing.
Structured PICO
P
Population
7 normal volunteers
I
Intervention
Observation under standardized conditions of dietary sodium, posture, and physical activity over 24 hours, followed by a 2-day period of severe sodium depletion
O
Outcome
Diurnal changes in plasma concentrations of atrial natriuretic peptide (ANP), renin, angiotensin II, aldosterone, cortisol, and antidiuretic hormonesurrogate
Plasma ANP exhibits a diurnal variation that correlates with cumulative sodium balance in normal volunteers.
Cite This Study
Richards et al. (1987) studied this question.