Why the study?
What are the autopsy and histological findings in patients with Ewing's sarcoma treated with radiation and adjuvant chemotherapy?
What are the autopsy and histological findings in patients with Ewing's sarcoma treated with radiation and adjuvant chemotherapy?
Autopsy of Ewing's sarcoma patients treated with radiation and chemotherapy reveals high rates of metastasis and residual primary tumor, with persistent intracytoplasmic glycogen despite histological changes.
High metastasis and residual tumor rates at autopsy indicate limited local control in Ewing's sarcoma; hypothesis-generating and should not yet change practice.
An autopsy study of 26 cases of Ewing's sarcoma treated with radiation to the primary site plus adjuvant chemotherapy has shown metastatic tumor in 23 cases. Metastases were found typically in lungs, pleura, bones and regional lymph nodes. In three cases no tumor could be found at autopsy, and death was due to complications of treatment. Tumor was found in the irradiated primary site in 13 of the 20 cases in which the primary site was examined at autopsy. Histologically, the tumor at autopsy frequently had increased pleomorphism and increased numbers of bizarre giant cells; however, these changes did not affect the presence of glycogen in tumor cells, thus reaffirming the importance of intracytoplasmic glycogen in the diagnosis of Ewing's sarcoma.
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Telles et al. (1978) studied this question.
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