Key result
Liquid chromatography successfully separated doxorubicin and its imine derivative with a resolution of 1.81 minutes, yielding 784 plates for doxorubicin and 6834 plates for the derivative.
Doxorubicin and its imine derivative can be successfully separated and identified using HPLC with a methanol/water mobile phase.
No takes yet. Share an insight, caveat, or question.
May support doxorubicin analytics in research labs; leaves open clinical translation in cardio-oncology.
Ronald Bartzatt (2006) studied this question. Liquid chromatography (HPLC) was evaluated on Resolution and theoretical plates for separation. Liquid chromatography successfully separated doxorubicin and its imine derivative with a resolution of 1.81 minutes, yielding 784 plates for doxorubicin and 6834 plates for the derivative.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: