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October 1, 1995Neurological Research

On the origin of cerebrovascular microemboli associated with prosthetic heart valves

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Why the study?

Does damping the closure of a mechanical prosthetic heart valve reduce the generation of microemboli signals in an in vitro model?

Population

In vitro model using a pulse duplicator filled with a seeded saline solution to function prosthetic heart…

Comparison

Damping the harsh closure of the mechanical… vs Undamped Björk-Shiley Monostrut valve

Design

Preclinical

Authors

TMTom G. MackayPennsylvania State UniversityDGDimitrios GeorgiadisHarokopio University of AthensDGDonald G. GrossetQueen Mary University of London

Discussion

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Implication

May inform mechanical valve design optimization; leaves open whether damping reduces clinical events in patients.

Structured PICO

Does damping the closure of a mechanical prosthetic heart valve reduce the generation of microemboli signals in an in vitro model?

P
Population
In vitro model using a pulse duplicator filled with a seeded saline solution to function prosthetic heart valves under mock-physiological conditions
I
Intervention
Damping the harsh closure of the mechanical valve (Björk-Shiley Monostrut valve) by applying a thin layer of soft adhesive tape between the valve occluder and outer ring
C
Comparator
Undamped Björk-Shiley Monostrut valve
O
Outcome
Number of transient high intensity Doppler signals (microemboli signals) detected downstreamsurrogate

Doppler microemboli signals can be generated by prosthetic heart valves in the absence of blood elements, and their number depends on the rate of energy dissipation at valve closure.

Cite This Study

Mackay et al. (1995) studied this question.

synapsesocial.com/papers/6a954792cd304312aafa763dhttps://doi.org/10.1080/01616412.1995.11740341
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Transcranial Doppler detection of microemboli in prosthetic heart valve patients: dependency upon valve type1996 · 31 citations
  2. 2Prevalence and characteristics of intracranial microemboli signals in patients with different types of prosthetic cardiac valves.1994 · 124 citations
  3. 3Coagulation activity and emboli counts in patients with prosthetic cardiac valves.1994 · 49 citations
  4. 4Variability of Doppler Microembolic Signal Counts in Patients With Prosthetic Cardiac Valves1995 · 41 citations
  5. 5Origin and Appearance of HITS Induced by Prosthetic Heart Valves: An in vitro Study2000 · 18 citations