Why the study?
Group H Rotavirus is associated with human diarrhea gastroenteritis, but the interferon response induced by it remains unclear.
The study elucidates the mechanisms by which human group H rotavirus induces and suppresses interferon responses, highlighting the roles of viral proteins NSP1 and NSP5.
Group H Rotavirus (RVH) is associated with human diarrhea gastroenteritis. The interferon (IFN) response induced by RVH remains unclear. In this study, we first studied the characteristic feature of RVH and found J19 strain of RVH grew less efficiently compared with the G6P1 strain of RVA. Next, we found that infection with the J19 virus resulted in the secretion of IFN-λ1, but not IFN-β, while both IFN-β and IFN-λ1 could inhibit J19 replication significantly in Caco-2 cells. NSP1 played an important role in the suppression of type I and type III IFN response, and NSP5 protein significantly inhibited activation of IFN-λ1. J19 NSP1 suppressed the induction of IFN-β obviously than G6P1 NSP1, while G6P1 NSP1 reduced IFN-λ1 induction to the greatest extent compared with G9P8, Wa, and J19 NSP1s. Our studies reveal the propagation feature of RVH and interferon induction and suppression by group H rotavirus.
No takes yet. Share an insight, caveat, or question.
Liu et al. (2023) studied Human diarrhea gastroenteritis. Group H Rotavirus (RVH) J19 strain vs. Group A Rotavirus (RVA) G6P1 strain was evaluated on Interferon (IFN) response (IFN-λ1 and IFN-β secretion and suppression).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: