Key result
Mumps virus was detected in 1.2% (3/260) of cerebrospinal fluid specimens, with phylogenetic analysis linking one strain to vaccine strains potentially associated with aseptic meningitis.
Observational (n=260)
No
This study provides viral proof that mumps vaccine-like strains may be associated with aseptic meningitis.
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Rare MuV detection in CSF may warrant targeted testing in meningitis; leaves open strain surveillance needs in Africa.
The study aimed to determine the presence of mumps virus (MuV) in cerebrospinal fluid (CSF) specimens and to genetically characterise detected MuV strains. A real-time reverse transcription-polymerase chain reaction (RT-PCR) was used to detect the MuV F gene, and characterisation was performed by sequencing of the SH gene. Mumps virus was detected in 1.2% (3/260) of specimens. Phylogenetic analysis of one MuV strain revealed that it clustered with the Jeryl-Lynn and RIT4385 vaccine strains. As far as the authors could ascertain this is the first study to provide viral proof that these vaccine-like strains may be associated with aseptic meningitis.
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Brauer et al. (2015) conducted an observational in Aseptic meningitis (n=260). Mumps virus (MuV) in cerebrospinal fluid was evaluated on Presence of mumps virus (MuV) in cerebrospinal fluid (CSF) specimens. Mumps virus was detected in 1.2% (3/260) of cerebrospinal fluid specimens, with phylogenetic analysis linking one strain to vaccine strains potentially associated with aseptic meningitis.
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