Key result
Intravenous administration of phenoxybenzamine abolished spinal cord autoregulation, causing spinal cord blood flow to vary linearly with changes in mean systemic arterial blood pressure.
Why the study?
Does alpha adrenergic blockade with phenoxybenzamine abolish spinal cord blood flow autoregulation in monkeys?
Does alpha adrenergic blockade with phenoxybenzamine abolish spinal cord blood flow autoregulation in monkeys?
Alpha adrenergic blockade abolishes spinal cord blood flow autoregulation in monkeys, suggesting the sympathetic nervous system plays a dominant role in controlling spinal circulation.
Answers are grounded in this paper and cite their sources.
Indicates sympathetic dominance in primate spinal autoregulation; leaves open relevance to human spinal perfusion.
✓ Spinal cord blood flow (SCBF) was measured over a wide range of artificially varied mean systemic arterial blood pressures (MAP) in a group of monkeys with alpha adrenergic receptors blocked by the intravenous administration of phenoxybenzamine (Dibenzyline). The SCBF was found to vary linearly with changes in MAP. Autoregulation appeared to have been abolished. These data are cited as evidence for a dominant role of the sympathetic nervous system in control of the spinal circulation.
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Kobrine et al. (1977) studied this question. Phenoxybenzamine (Dibenzyline) was evaluated on Spinal cord blood flow (SCBF) response to changes in mean systemic arterial blood pressure (MAP). Intravenous administration of phenoxybenzamine abolished spinal cord autoregulation, causing spinal cord blood flow to vary linearly with changes in mean systemic arterial blood pressure.
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