Key result
Sympathetic blockade exacerbates diurnal drops in cardiac output and rises in peripheral resistance.
Why the study?
The mechanisms underlying the diurnal variation of hemodynamic patterns and the role of the sympathetic nervous system in these variations were unclear.
Does sympathetic blockade eliminate the diurnal variation of hemodynamic patterns in monkeys?
Does sympathetic blockade eliminate the diurnal variation of hemodynamic patterns in monkeys?
Sympathetic blockade exacerbates rather than eliminates the diurnal variation of hemodynamic patterns in monkeys, suggesting the sympathetic nervous system attenuates these events.
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Should not alter clinical sympathetic blockade; leaves open translation of primate diurnal hemodynamics to humans.
Talan et al. (1989) studied this question. Sympathetic blockade (prazosin, atenolol, or both) vs. Baseline data was evaluated on Diurnal variation of hemodynamic patterns (cardiac output and total peripheral resistance). Sympathetic blockade with prazosin, atenolol, or both exacerbated the diurnal fall in cardiac output and rise in total peripheral resistance in monkeys.
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