Why the study?
Does chronic peripheral muscarinic blockade with scopolamine methyl bromide increase blood pressure, heart rate, and blood pressure variability in Sprague-Dawley rats?
Does chronic peripheral muscarinic blockade with scopolamine methyl bromide increase blood pressure, heart rate, and blood pressure variability in Sprague-Dawley rats?
Chronic peripheral muscarinic blockade in rats leads to modest but sustained increases in blood pressure, heart rate, and blood pressure variability, suggesting a role for parasympathetic dysfunction in cardiovascular risk.
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May link peripheral parasympathetic blockade to BP variability; leaves open translation to human hypertension risk.
Ayer et al. (2007) studied this question.
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