Key result
Familial hyperbetalipoproteinaemia was associated with significantly lower fractional rates of HDL and LDL cholesteryl ester turnover compared to controls, with no difference in absolute rates.
Observational
Familial hyperbetalipoproteinaemia is associated with lower fractional turnover rates of HDL and LDL cholesteryl esters, but absolute turnover rates remain similar to healthy controls.
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Should not change lipid management in familial hyperbetalipoproteinaemia; leaves open whether fractional turnover rates affect cardiovascular risk.
The turnover of cholesteryl esters in plasma high-density (HDL) and low-density (LDL) lipoproteins was measured in patients with familial hyperbetalipoproteinaemia in the homozygous and heterozygous forms and in control subjects. 2. The fractional rates of turnover of HDL and LDL cholesteryl esters were significantly lower in the patients than in the control subjects, but there was no significant difference between the absolute rates of turnover (expressed in mg h−1 kg body wt.−1) in the patients and controls.
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Myant et al. (1973) conducted an observational in Familial hyperbetalipoproteinaemia. Familial hyperbetalipoproteinaemia vs. Control subjects was evaluated on Turnover of cholesteryl esters in plasma high-density (HDL) and low-density (LDL) lipoproteins. Familial hyperbetalipoproteinaemia was associated with significantly lower fractional rates of HDL and LDL cholesteryl ester turnover compared to controls, with no difference in absolute rates.
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