September 14, 2004Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy
History of Depression as a Predictor of Adverse Outcomes in Patients Hospitalized for Decompensated Heart Failure
Key result
A history of depression was associated with a significantly increased risk of in-hospital death or CPR compared to no history of depression (17.7% vs 6.6%; OR 3.3, 95% CI 1.01-10.6; p<0.05).
Why the study?
Does a history of depression increase the risk of in-hospital death or CPR in patients hospitalized for decompensated heart failure?
Population
171 patients hospitalized with decompensated heart failure who were included in the Acute Decompensated…
Comparison
History of depression vs No history of depression
Design
Cohort
Follow-up
in-hospital
Authors
Discussion
Loading...
Member takes
Implication
Supports heightened in-hospital monitoring for decompensated HF patients with depression history; leaves open whether screening or treatment improves outcomes.
Study Design
Type
Observational (n=171)
Multicenter
No
Structured PICO
Does a history of depression increase the risk of in-hospital death or CPR in patients hospitalized for decompensated heart failure?
P
Population
171 patients hospitalized with decompensated heart failure evaluated for in-hospital outcomes.
E
Exposure
History of depression
C
Comparator
No history of depression
O
Outcome
Combined end point of in-hospital death or need for cardiopulmonary resuscitation (CPR)composite
Main Result
Odds Ratio: 3.3 (95% CI 1.01–10.6)
Absolute Event Rate: 17.7% vs 6.6%
p-value: p=<0.05
A history of depression is a significant independent predictor of in-hospital mortality or need for CPR in patients admitted for decompensated heart failure.
Limitations
- Requires confirmation in larger trials
- single-center study
- requires confirmation in larger trials
Cite This Study
Denus et al. (2004) conducted an observational in Decompensated heart failure (n=171). History of depression vs. No history of depression was evaluated on In-hospital death or need for cardiopulmonary resuscitation (CPR) (OR 3.3, 95% CI 1.01-10.6, p=<0.05). A history of depression was associated with a significantly increased risk of in-hospital death or CPR compared to no history of depression (17.7% vs 6.6%; OR 3.3, 95% CI 1.01-10.6; p<0.05).