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June 30, 2017Journal of Proteome Research

Comprehensive Myocardial Proteogenomics Profiling Reveals C/EBPα as the Key Factor in the Lipid Storage of ARVC

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Key result

Proteogenomics profiling of ARVC hearts revealed lipid metabolism reprogramming driven by C/EBPα activation and upregulation of lipogenesis targets compared to DCM and normal hearts.

Population

Explanted human hearts: 4 ARVC, 4 DCM, and normal hearts for proteomics; 10 ARVC right ventricles and 4…

Comparison

Comprehensive myocardial proteogenomics profiling vs DCM explanted hearts and nondiseased donor hearts

Design

Preclinical

Authors

LCLiang ChenFudan UniversityFYFan YangNantong UniversityMRMan RaoSouthern University of Science and Technology

Discussion

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Implication

TMT proteomics of ARVC myocardium extends limited prior profiling; hypothesis-generating for biomarkers and mechanisms.

Study Design

Type

Observational

Structured PICO

P
Population
Explanted hearts from patients with ARVC, DCM, and normal donors analyzed via quantitative proteomics and RNA sequencing.
E
Exposure
Comprehensive myocardial proteogenomics profiling (TMT-labeled LC-MS/MS and RNA sequencing)
C
Comparator
DCM explanted hearts and nondiseased donor hearts
O
Outcome
Proteome and transcriptome pattern characteristicssurrogate

Comprehensive proteogenomic profiling identifies C/EBPα-driven lipid metabolism reprogramming as a hallmark of ARVC, providing potential new molecular targets.

Cite This Study

Chen et al. (2017) conducted an observational in Arrhythmogenic right ventricular cardiomyopathy (ARVC). Arrhythmogenic right ventricular cardiomyopathy (ARVC) vs. Dilated cardiomyopathy (DCM) and normal hearts was evaluated on Proteome and transcriptome patterns. Proteogenomics profiling of ARVC hearts revealed lipid metabolism reprogramming driven by C/EBPα activation and upregulation of lipogenesis targets compared to DCM and normal hearts.

synapsesocial.com/papers/6a9579d2a15fb1352cb2fcf7https://doi.org/10.1021/acs.jproteome.7b00165
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