Key result
Myocardial transcriptome analysis of ARVC hearts revealed no distinct expression pattern between left and right ventricles, but showed clear separation from nonfailing and DCM samples.
Population
19 explanted human hearts: 6 with arrhythmogenic right ventricular cardiomyopathy, 7 with idiopathic dilated…
Comparison
Transcriptome analysis of left and right… vs Nonfailing donor hearts and DCM hearts
Design
Preclinical
Authors
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ARVC transcriptomes separate distinctly from DCM/controls without LV-RV differences; hypothesis-generating for molecular classification but should not yet change practice.
Observational (n=19)
Transcriptome analysis demonstrates that end-stage ARVC has a distinct molecular signature compared to DCM and lacks significant regional (LV vs RV) gene expression differences.
Gaertner et al. (2011) conducted an observational in Arrhythmogenic right ventricular cardiomyopathy (n=19). Arrhythmogenic right ventricular cardiomyopathy vs. Nonfailing donor hearts and idiopathic dilated cardiomyopathy was evaluated on Myocardial transcriptome expression patterns. Myocardial transcriptome analysis of ARVC hearts revealed no distinct expression pattern between left and right ventricles, but showed clear separation from nonfailing and DCM samples.
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