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August 1, 2016The International Journal of Artificial Organs

Transcatheter aortic valve implantation in elderly patients was associated with incremental increases in quality of life VAS scores over 12 months (p<0.001) and a 12-month all-cause mortality of 17.8%.

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Why the study?

Does transcatheter aortic valve implantation (TAVI) improve quality of life and all-cause mortality in elderly patients at 12 months?

Population

101 elderly patients undergoing transcatheter aortic valve implantation (TAVI)

Design

Cohort

Follow-up

12 months

Key result

Transcatheter aortic valve implantation in elderly patients was associated with incremental increases in quality of life VAS scores over 12 months (p<0.001) and a 12-month all-cause mortality of 17.8%.

Authors

PKPaweł KleczyńskiMBMaciej BagieńskiADArtur Dziewierz

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Overview

TAVI may support QoL consideration in elderly patients; leaves open randomized confirmation of benefits versus alternatives.

Key Points

  • To evaluate longitudinal changes in quality of life and track all-cause mortality rates over a 12-month period in elderly patients undergoing transcatheter aortic valve replacement.
  • Followed 101 elderly patients undergoing transcatheter aortic valve implantation (TAVI) over a 12-month follow-up window.
  • Assessed health-related quality of life at baseline, 1 month, 6 months, and 12 months using the EQ-5D-3L questionnaire and a visual analog scale (VAS).
  • Visual analog scale scores increased progressively over follow-up (p < 0.001), with marked 12-month improvements in mobility (p = 0.001) and anxiety (p = 0.003), though self-care (p = 0.41), usual activity (p = 0.12), and pain (p = 0.27) did not significantly change.
  • Patients receiving transfemoral access reported significantly higher VAS scores at 1 month compared to non-transfemoral access (median 65.0 vs. 54.0; p = 0.019), but this difference attenuated by 12 months (70.0 vs. 67.5; p = 0.07).
  • Cumulative all-cause mortality reached 6.9% in-hospital, 10.9% at 1 month, 15.8% at 6 months, and 17.8% at 12 months post-procedure.

Study Design

Type

Cohort (n=101)

Structured PICO

Does transcatheter aortic valve implantation (TAVI) improve quality of life and all-cause mortality in elderly patients at 12 months?

P
Population
101 elderly patients who underwent TAVI, followed for 12 months to assess quality of life and mortality.
E
Exposure
Transcatheter aortic valve implantation (TAVI)
O
Outcome
Changes in Quality of Life (assessed via EQ-5D-3L with a visual analog scale) and all-cause mortality at 12 monthspatient reported

Main Result

p-value: p=<0.001

TAVI significantly improves overall quality of life, specifically mobility and anxiety, in elderly patients at 12 months, with transfemoral access offering better early quality of life compared to non-transfemoral access.

Cite This Study

Kleczyński et al. (2016) conducted a cohort in Elderly patients undergoing transcatheter aortic valve implantation (TAVI) (n=101). Transcatheter aortic valve implantation (TAVI) was evaluated on Changes in quality of life (VAS score) and all-cause mortality at 12 months (p=<0.001). Transcatheter aortic valve implantation in elderly patients was associated with incremental increases in quality of life VAS scores over 12 months (p<0.001) and a 12-month all-cause mortality of 17.8%.

synapsesocial.com/papers/6a9590157007bd2ef4e3cc8ahttps://doi.org/10.5301/ijao.5000521
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Short- and intermediate-term improvement of patient quality of life after transcatheter aortic valve implantation: a single-centre study2014 · 34 citations
  2. 2Quality of life in patients with transcatheter aortic valve implantation: an analysis from the INTERVENT project2023 · 7 citations
  3. 3Improvement of physical and mental health after transfemoral transcatheter aortic valve implantation2012 · 21 citations
  4. 4Quality-of-life in elderly patients one year after transcatheter aortic valve implantation for severe aortic stenosis2011 · 55 citations
  5. 5Quality of life improvement is maintained up to two years after transcatheter aortic valve implantation in high-risk surgical candidates2012 · 25 citations