Key result
Postoperative plasma D-dimer concentration on days 1, 3, and 7 demonstrated moderate predictive value for DVT following total hip arthroplasty, with AUCs of 0.706, 0.712, and 0.772.
Why the study?
Does postoperative plasma D-dimer value predict deep venous thrombosis in patients undergoing hip arthroplasty with nadroparin prophylaxis?
Observational (n=83)
Does postoperative plasma D-dimer value predict deep venous thrombosis in patients undergoing hip arthroplasty with nadroparin prophylaxis?
Postoperative D-dimer concentrations on days 1, 3, or 7 have moderate predictive value for DVT in patients undergoing total hip arthroplasty with nadroparin prophylaxis.
Answers are grounded in this paper and cite their sources.
D-dimer may aid postoperative DVT risk stratification after hip arthroplasty; leaves open whether serial testing improves outcomes over nadroparin alone.
The aim of the study was to assess the value of D-dimer as an event predicitor for deep vein thrombosis (DVT) in patients given low molecular weight heparin (LMWH) after total hip arthroplasty (THA). Plasma D-dimer levels were obtained preoperatively and at days 1, 3, and 7 postoperatively in 83 consecutive patients undergoing THA treated with nadroparin prophylaxis plus intermittent pneumatic compression. Unilateral ascending venography was performed at postoperative day 7 or 8. There was a significant difference between the D-dimer levels in the DVT group (28 patients) and non-DVT group (55 patients) on each day (P<0.01). ROC analysis showed the AUC on postoperative days 1, 3 and 7 was 0.706, 0.712 and 0.772 respectively. The D-dimer concentration on postoperative day 1, day 3 or day 7 is of moderate predicting value of DVT in patients undergoing THA, treated with nadroparin prophylaxis plus intermittent pneumatic compression.
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Xu et al. (2013) conducted an observational in Deep vein thrombosis following total hip arthroplasty (n=83). Postoperative plasma D-dimer levels was evaluated on Deep vein thrombosis (DVT) (AUC 0.772 on day 7, p=<0.01). Postoperative plasma D-dimer concentration on days 1, 3, and 7 demonstrated moderate predictive value for DVT following total hip arthroplasty, with AUCs of 0.706, 0.712, and 0.772.
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