Key result
In a patient with Brugada syndrome, a near-fatal electrical storm aggravated by amiodarone was successfully resolved with isoproterenol.
Case Report (n=1)
Isoproterenol may be effective in resolving electrical storm in Brugada syndrome that is aggravated by conventional antiarrhythmics like amiodarone.
Isoproterenol may aid refractory Brugada storm; single case leaves open need for prospective validation before practice change.
Brugada syndrome (BS) may be "unmasked" by several pharmacological and/or physiological agents in an otherwise normal electrocardiogram. Once diagnosed the possibility of persistent ventricular tachycardia/fibrillation exists. Although this is treated with various antiarrhythmic agents, there remains a cohort of patients who fail to respond to conventional antiarrhythmic therapy therefore, amplifying the electrical storm. We report a case of a BS diagnosed via procainamide challenge, the resultant near fatal electrical storm aggravated by amiodarone and the eventual resolution with isoproterenol.
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Joshi et al. (2007) conducted a case report in Brugada syndrome (n=1). Isoproterenol was evaluated on Resolution of electrical storm. In a patient with Brugada syndrome, a near-fatal electrical storm aggravated by amiodarone was successfully resolved with isoproterenol.
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