Key result
5-fluorouracil infusion linked to prolonged ventricular storm and unmasked Brugada syndrome.
Case Report (n=1)
This case report identifies 5-fluorouracil as a previously unreported potential inducer of Brugada syndrome and electrical storm.
5-Fluorouracil may trigger Brugada storm; this single case extends known drug associations but leaves open causal confirmation.
BACKGROUND: Brugada syndrome is a disorder associated with an increased risk of syncope, ventricular fibrillation, and sudden cardiac death in a structurally normal heart. The condition is related to mutations in cardiac cell transmembrane channels, but many cases do not have identifiable genetic mutations. Arrhythmic events are usually induced by specific triggers including a number of medications. Ventricular storm in Brugada syndrome is rare but when it occurs it can be life threatening. CASE SUMMARY: We present a case of a patient receiving 5-fleurouracil home infusion monotherapy who developed prolonged ventricular storm and was found to have previously undiagnosed Brugada syndrome. The patient was successfully treated with isoproterenol, quinidine, and arrhythmogenic trigger reduction and made a full recovery. DISCUSSION: 5-flourouracil has never previously been reported as a possible inducer of Brugada syndrome. Additionally, this is the most prolonged case of electrical storm in a patient with Brugada syndrome reported to date.
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Melnychuk et al. (2025) conducted a case report in Brugada syndrome and ventricular storm (n=1). 5-fluorouracil was evaluated on Ventricular storm and Brugada syndrome induction. 5-fluorouracil home infusion monotherapy was identified as a novel trigger for prolonged ventricular storm and unmasking of previously undiagnosed Brugada syndrome in a single patient.
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