Key result
A microfluidic chip-based hydrodynamic focusing approach successfully quantified platelet surface coverage and aggregate size distributions using ~50 μL of whole blood in a 2-minute assay.
Population
Undiluted whole blood samples for in vitro platelet adhesion analysis
Design
Preclinical
Authors
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May advance preclinical platelet assays with minimal volumes; leaves open human validation for point-of-care use.
A novel microfluidic approach enables rapid, low-volume assessment of platelet adhesion under arterial shear conditions, with potential applications for point-of-care diagnostics.
Kent et al. (2010) studied this question. Microfluidic chip-based hydrodynamic focusing approach was evaluated on Cellular surface coverage and aggregate size distributions. A microfluidic chip-based hydrodynamic focusing approach successfully quantified platelet surface coverage and aggregate size distributions using ~50 μL of whole blood in a 2-minute assay.
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