Key result
Mitral valve repair was associated with a lower perioperative mortality (OR 0.61) but a higher recurrence of mitral regurgitation (OR 4.09) compared with replacement for severe ischemic mitral regurgitation.
Why the study?
Does mitral valve repair reduce perioperative mortality and improve long-term survival compared to mitral valve replacement in patients with severe ischemic mitral regurgitation?
Population
13 studies pooling 1993 patients with severe ischemic mitral regurgitation (IMR)
Comparison
Mitral valve repair (MVP) vs Mitral valve replacement (MVR)
Design
Meta-analysis
Authors
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Supports repair to lower perioperative mortality in severe ischemic MR; leaves optimal long-term strategy open given higher recurrence.
Meta-Analysis (n=1,993)
Does mitral valve repair reduce perioperative mortality and improve long-term survival compared to mitral valve replacement in patients with severe ischemic mitral regurgitation?
Odds Ratio: 0.61 (95% CI 0.43–0.87)
p-value: p=<.05
In patients with severe ischemic mitral regurgitation, mitral valve repair is associated with lower perioperative mortality but higher MR recurrence compared to replacement, with no significant difference in long-term survival.
Wang et al. (2018) conducted a meta-analysis in Severe ischemic mitral regurgitation (n=1,993). Mitral valve repair vs. Mitral valve replacement was evaluated on Perioperative mortality (OR 0.61, 95% CI 0.43-0.87, p=<.05). Mitral valve repair was associated with a lower perioperative mortality (OR 0.61) but a higher recurrence of mitral regurgitation (OR 4.09) compared with replacement for severe ischemic mitral regurgitation.
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