Key result
Mitral valve repair was associated with lower operative mortality (OR 0.45; 95% CI 0.31-0.65; p<0.0001) but higher recurrence of mitral regurgitation compared with mitral valve replacement.
Why the study?
Does mitral valve repair improve outcomes compared to mitral valve replacement in patients with chronic ischemic mitral regurgitation?
Population
2,324 patients with chronic ischemic mitral regurgitation pooled from 10 retrospective studies
Comparison
Mitral valve repair vs Mitral valve replacement
Design
Meta-analysis
Follow-up
5 years
Authors
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Supports repair to reduce operative mortality in ischemic MR; extends evidence on higher recurrence versus replacement.
Meta-Analysis (n=2,324)
Does mitral valve repair improve outcomes compared to mitral valve replacement in patients with chronic ischemic mitral regurgitation?
Odds Ratio: 0.45 (95% CI 0.31–0.65)
p-value: p=< 0.0001
In patients with chronic ischemic mitral regurgitation, mitral valve repair offers lower operative mortality but a higher risk of recurrent regurgitation compared to replacement, with similar 5-year survival.
Deng et al. (2016) conducted a meta-analysis in chronic ischemic mitral regurgitation (n=2,324). Mitral valve repair vs. Mitral valve replacement was evaluated on Operative mortality (OR 0.45, 95% CI 0.31-0.65, p=< 0.0001). Mitral valve repair was associated with lower operative mortality (OR 0.45; 95% CI 0.31-0.65; p<0.0001) but higher recurrence of mitral regurgitation compared with mitral valve replacement.